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Importance of (PGT) Pre Genetic Diagnostic Testing

IVF Clinic Surrogacy
May 14, 2022

Introduction

Genetic abnormalities are the term that haunts couples who are concerned about their future baby. Diagnosis of such abnormalities and eliminating the risk or reducing the risk of spreading a genetic disease can be possible via PGD (preimplantation genetic diagnosis). It is a technique used for the identification of genetic defects in the embryos which were produced in the lab via IVF. It is done before embryos are implanted into the uterus. PGD is advised for couples whose either one or both partners have any genetic defects. Since diagnostic procedures like amniocentesis or Chorionic villus testing may have unfavorable results which may lead to taking harsh steps such as pregnancy termination. Hence, currently, PGD and PGS is a better technique that helps in avoiding having a child with genetic defects.  

Merits of PGD

  • Helps in selecting healthy embryos for implantation.
  • Helps in the diagnosis of the reason behind miscarriage.
  • Prevents pregnancy losses.
  • Prevents financial loss.

What does PGD involve?

After fertilization during an IVF/ ICSI cycle, the embryos are cultured and blastomere biopsy is performed on embryos at the 6 – 8 cell stage which is generally achieved by embryos at day 3 post-fertilization. During biopsy 1 or 2 embryos are selected for the biopsy. Once the biopsy is done embryos are kept in culture till the result arrives. Once the result arrives safe embryos are transferred into the uterus.

Whom Can PGD Help

PGD in general can help couples who are seeking a better and healthy future for their babies through IVF. Though speaking in specific PGD can be more beneficial to :

  • If a female partner is above 38 years of age.
  • Multiple miscarriages occurred in previous IVF cycles.
  • Have any hereditary genetic disorder which has a risk of passing it to the next generation.

Why PGD is required:

Since, PGD is a less invasive method than known Amniocentesis and Chorionic villus testing techniques and also embryos are chosen on the basis of visual quality and morphology, which doesn’t say much about the chromosomal abnormalities and cannot distinguish between normal and affected embryo. PGD becomes the best available method to screen and have healthy embryos currently.

Disadvantages of PGD:

  • It is an invasive procedure.
  • Cannot detect genetic mosaicism.
  • Can only test 11 out of 23 known pairs of chromosomes. 
  • May lead to no transfer if all embryos have defects.

Conclusion: 

Though PGD is an invasive technique and only could detect limited chromosomal defects even then it’s a better-known method of humankind. As there ain’t any test which can detect all the chromosomal abnormalities. Still, advancement in genetic testing gives hope to many couples who plan to have healthy babies through IVF. 

How Zoi Fertility Can help:

Zoi Fertility aims toward having a brighter future for you and your baby. Zoi along with their professional team are very well known for the care given to their patients and for conducting IVF cycles with utmost care. To know more about PGD and if you have queries about infertility contact us.

Life@ZoiFertility.com

Phone: 9821506000

References:

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