My Fertility Query
Do I need PGS / PGD
One of the most common reasons why IVF is unsuccessful, is chromosomal abnormalities in the embryo.
Is it for me?
It is suited for couples where:
- The woman is aged 38 or older
- There is a history of recurrent miscarriage
- There has been repeated IVF failure, for example 5 or more embryos have been replaced without success
- There has previously been a chromosomally abnormal pregnancy (eg Down syndrome)
If the cells of an embryo contain the wrong number of chromosomes (aneuploidy), causes the embryo to develop abnormally. Women over 38 years of age are at greatest risk.
Sometimes pieces of chromosomes break off and attach to the ends of other chromosomes. Embryos with unbalanced translocations will usually miscarry or fail to implant.
At Zoi, we believe advanced embryo selection is important, as up to 30% of embryos thought to be normal had an error (chromosome abnormality) on another chromosome that they were not able to test.
Testing for genetic diseases
Humans have up to 20,000 different genes. When the DNA sequence on a particular gene is altered, a genetic abnormality may result. It is now possible to test embryos for many single gene disorders or chromosomal abnormalities with Pre-Implantation Genetic Diagnostics.