My Fertility Query
Do I need PGS / PGD
Embryo Chromosomal problems
One of the most common reasons why IVF or ICSI is unsuccessful is chromosomal abnormalities in the embryo.
Is PGT (PGD/PGS) for me?
PGD/PGS or PGT A/PGT M is suited for couples where:
- The woman is aged 38 or older
- There is a history of recurrent miscarriages
- There has been repeated IVF failure, for example, 5 or more embryos have been replaced without success
- There has previously been a chromosomally abnormal pregnancy (eg: Down syndrome)
Abnormal Chromosomes
If the cells of an embryo contain the wrong number of chromosomes (aneuploidy), causes the embryo to develop abnormally. Women over 38 years of age are at the greatest risk.
Sometimes pieces of chromosomes break off and attach to the ends of other chromosomes. Embryos with unbalanced translocations will usually miscarry or fail to implant.
Embryo Selection
At Zoi, we believe advanced embryo selection is important, as up to 30% of embryos thought to be normal had an error (chromosome abnormality) on another chromosome that they were not able to test.
Common Conditions of abnormalities
- Down Syndrome
- Klinefelter Syndrome
- Turner Syndrome
- Cystic Fibrosis (though not in India)
- Hemophilia A
- Sickle cell anemia
Additional Benefits of PGS / PGD (PGT) includes
- Help reduce the chance of a miscarriage
- Help rule out abnormal growth of the fetus
- Increases the possibility of pregnancy/success rate in IVF
- Can save money, by decreasing the total number of IVF and embryo transfers required
New Names for PGD and PGS
All tests are renamed henceforth for fertility treatments as PGT. When the test is done for aneuploidies, it is called PGT-A and when done for mono/single, it is named PGT-M.
